Visible-Light-Driven Base-Promoted Radical Cascade Difluoroalkylation-Cyclization-Iodination of 1,6-Enynes with Ethyl Difluoroiodoacetate

被引：8
作者：
Wang, Yan [1 ]
Liu, Ruyan [1 ]
Zhou, Pengsheng [1 ]
Wu, Jianglong [1 ]
Li, Wenshuang [1 ]
Wang, Chenyu [1 ]
Li, Hao [1 ]
Li, Dianjun [1 ,2 ]
Yang, Jinhui [1 ,2 ]
机构：
[1] Ningxia Univ, Sch Chem & Chem Engn, 489 Helanshan West Rd, Yinchuan, Ningxia, Peoples R China
[2] Ningxia Univ, State Key Lab High Efficiency Utilizat Coal & Gre, 489 Helanshan West Rd, Yinchuan, Ningxia, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Base-promoted; Cyclization; Difluoroalkylation; Radical reactions; Visible-light-driven; ELECTRON-TRANSFER; FLUORINE; METALLAPHOTOREDOX; ALKYLATION; ARYLATION;
D O I：
10.1002/ejoc.202101395
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light-driven base-promoted radical cascade difluoroalkylation/5-exo-dig cyclization/iodination of 1,6-enynes with ethyl difluoroiodoacetate was developed under catalyst-free and oxidant-free conditions. The difluoroalkylated pyrrolidines and tetrahydrofuran derivatives were generated with good functional group tolerance and high Z/E stereoselectivity. This reaction provided an alternative and mild method for the preparation of highly functionalized and vinyl C-I bonds containing five-membered heterocyclic products.
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页数：4
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