Adiposity, Weight Change, and Risk of Cognitive Impairment: The Singapore Chinese Health Study

被引:16
作者
Talaei, Mohammad [1 ,2 ]
Feng, Lei [3 ]
Barrenetxea, Jon [4 ]
Yuan, Jian-Min [5 ,6 ]
Pan, An [7 ]
Koh, Woon-Puay [4 ,8 ]
机构
[1] Natl Univ Hlth Syst NUHS Ctr Hlth Ageing, Singapore, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore
[4] Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore, Singapore
[5] Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA USA
[6] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA
[7] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, gDept Epidemiol & Biostat,MOE Key Lab Environm &, Wuhan, Hubei, Peoples R China
[8] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
基金
英国医学研究理事会; 美国国家卫生研究院;
关键词
Body mass index; Chinese; cognitive impairment; cohort study; weight change; BODY-MASS INDEX; MINI-MENTAL-STATE; MENDELIAN RANDOMIZATION; ALZHEIMERS-DISEASE; FOLLOW-UP; LATE-LIFE; DEMENTIA; MIDLIFE; PEOPLE; TRAJECTORIES;
D O I
10.3233/JAD-191052
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Few prospective studies with long duration of follow-up have assessed the relations of body mass index (BMI) and weight change with cognitive function, especially in Asian populations. Objective: To investigate whether BMI and weight change in midlife are associated with cognitive impairment in old age. Methods: We used data from 14,691 participants in the Singapore Chinese Health Study and computed weight change as the difference between weight reported at baseline (1993-1998) at mean age of 53.0 years and follow-up 1 (1999-2004) at mean age of 58.6 years. Cognitive impairment was determined using education-specific cut-offs of the Singapore Modified Mini-Mental State Examination at follow-up 3 (2014-2016) at mean age of 72.9 years. We used multivariable logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations. Results: Obesity (as defined BMI >= 27.5 kg/m(2)) was associated with a higher risk of cognitive impairment at baseline (OR 1.33, 95% CI 1.12-1.58) and follow-up 1 (OR 1.30, 95% CI 1.10-1.54) compared to BMI of 18.5-22.9 kg/m(2). Underweight (BMI <18.5 kg/m(2)) was not associated with a significant risk either at baseline (OR 0.91, 95% CI 0.73-1.13) or follow-up 1 (OR 1.05, 95% CI 0.85-1.28). Compared to participants with <5% weight change, the ORs (95% CIs) of cognitive impairment were 1.20 (1.03-1.41) for those with 5-9.9% weight loss, 1.53 (1.29-1.81) for >= 10% weight loss, 1.00 (0.85-1.17) for 5-9.9% weight gain, and 1.50 (1.28-1.75) for >= 10% weight gain. Conclusion: Obesity, weight loss, and excessive weight gain at midlife were associated with an increased risk of cognitive impairment at old age.
引用
收藏
页码:319 / 329
页数:11
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