The microbiome, gastrointestinal cancer, and immunotherapy

被引：16

作者：

Newsome, Rachel C. ^{[1
]}

Yang, Ye ^{[1
]}

Jobin, Christian ^{[1
,2
,3
]}

机构：

[1] Univ Florida, Dept Med, 2033 Mowry Rd, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Infect Dis & Immunol, Gainesville, FL USA

[3] Univ Florida, Dept Anat & Cell Biol, Gainesville, FL USA

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2022年 / 37卷 / 02期

基金：

美国国家卫生研究院;

关键词：

antitumor immunity; colorectal cancer; liver cancer; microbiota; pancreatic cancer; FUSOBACTERIUM-NUCLEATUM; ANTI-PD-1; EFFICACY; COLORECTAL-CANCER; TUMOR MICROBIOME; IMMUNE-RESPONSE; GUT MICROBIOTA; RESISTANCE; COMBINATION; TRANSPLANT; NIVOLUMAB;

D O I：

10.1111/jgh.15742

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gastrointestinal tract greatly contributes to global cancer burden and cancer-related deaths. The microbiota represents the population of microorganisms that live in and around the body, located primarily in the gastrointestinal tract. The microbiota has been implicated in colorectal cancer development and progression, but its role in cancer therapy for the gastrointestinal tract is less defined, especially for extra-intestinal cancers. In this review, we discuss the past 5 years of research into microbial involvement in immune-related therapies for colorectal, pancreatic, hepatic, and gastric cancers, with the goal of highlighting recent advances and new areas for investigation in this field.

引用

页码：263 / 272

页数：10

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