Time-Economical Radical Cascade Cyclization/Haloazidation of 1,6-Enynes: Construction of Highly Functional Succinimide Derivatives

被引：33

作者：

Gu, Yan ^{[1
]}

Dai, Lei ^{[1
]}

Mao, Kaimin ^{[1
]}

Zhang, Jinghang ^{[1
]}

Wang, Chang ^{[1
]}

Zhao, Liming ^{[1
]}

Rong, Liangce ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ANTICONVULSANT PROPERTIES; EFFICIENT SYNTHESIS; CHLORINE AZIDE; GAMMA-LACTAMS; ATOM ECONOMY; STEP ECONOMY; CYCLIZATION; ENYNES; HYDROBORATION/CYCLIZATION; CYCLOISOMERIZATION;

D O I：

10.1021/acs.orglett.0c00682

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A "time-economical" radical cascade cyclization/haloazidation of 1,6-enynes provides a direct approach to access highly functional succinimide compounds. Moderate to excellent yields along with excellent Z/E ratio were obtained under the reaction features of broad substrate scope, good functional group tolerance, and mild reaction conditions.

引用

页码：2956 / 2960

页数：5

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