Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

被引：47

作者：

Arun, Ashni ^{[1
]}

Malrautu, Pratyusha ^{[1
]}

Laha, Anindita ^{[1
]}

Luo, Hongrong ^{[2
]}

Ramakrishna, Seeram ^{[3
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Inst Technol, Dept Chem Engn, Manipal 576104, India

[2] Sichuan Univ, Engn Res Ctr Biomat, Chengdu 610064, Peoples R China

[3] Natl Univ Singapore, Ctr Nanofibers & Nanotechnol, Singapore 117581, Singapore

来源：

APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 23期

关键词：

drug delivery systems (DDS); tissue engineering (TE); polymers; collagen; nanoparticle (NP); BIOMEDICAL APPLICATIONS; COMPOSITE SCAFFOLDS; BIOMATERIALS; POLYMERS; FUNCTIONALIZATION; FABRICATION; EFFICIENCY; FILMS;

D O I：

10.3390/app112311369

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

引用

页数：17

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