Multi-component synthesis and antimicrobial activity of novel imidazo[4,5-f] indol-7-yl)indolin-2-ones

被引：1

作者：

Reddy, Malladi Srinivas ^{[1
]}

Saini, Ramakrishna ^{[2
]}

Dontamalla, Sudheer Kumar ^{[3
]}

Suhasini, B. ^{[4
]}

机构：

[1] JNTU Hyderabad, Vaageswari Coll Pharm, Dept Pharmaceut Chem, Thimmapur, India

[2] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India

[3] KDR Govt Polytech, State Board Tech Educ & Training, Dept Pharm, Wanaparthy, India

[4] SVS Sch Pharm, Dept Pharmaceut Chem, Warangal, Andhra Pradesh, India

来源：

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2015年 / 97卷 / 07期

关键词：

imidazo[4,5-f]indol-7-yl)indolin-2-ones; ceric ammonium nitrate; multi-component reaction; antimicrobial activity; ALKALOIDS; DRUG;

D O I：

10.1080/02772248.2015.1060974

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A three-component one-pot protocol has been investigated for the synthesis of imidazo[4,5-f]indol-7-yl)indolin-2-ones from the commercially available materials. Structures of these compounds were established on the basis of IR, H-1 NMR, and mass spectral data. The title compounds were evaluated for their antimicrobial activity. Two compounds exhibited the potent antimicrobial activity.

引用

页码：839 / 846

页数：8

共 27 条

[11] 2H-BENZIMIDAZOLES (ISOBENZIMIDAZOLES) .10. SYNTHESIS OF POLYSUBSTITUTED O-PHENYLENEDIAMINES AND THEIR CONVERSION INTO HETEROCYCLES, PARTICULARLY 2-SUBSTITUTED BENZIMIDAZOLES WITH KNOWN OR POTENTIAL ANTHELMINTIC ACTIVITY [J].

HAZELTON, JC ;

IDDON, B ;

SUSCHITZKY, H ;

WOOLLEY, LH .

TETRAHEDRON, 1995, 51 (39) :10771-10794

[12]

ITO K, 1982, ARZNEIMITTEL-FORSCH, V32-1, P49

[13] Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog [J].

Kappe, CO .

ACCOUNTS OF CHEMICAL RESEARCH, 2000, 33 (12) :879-888

[14]

Loughlin WA, 2004, CHEM REV, V104, P6085, DOI 10.1021/cr040648k

[15]

Mancini G., 1996, HELV CHIM ACTA, V79, P2075

[16]

Margery L. E., 1962, PRACTICAL INTRO MICR, P177

[17] Synthesis and serotonergic activity of 2-oxadiazolyl-5-substituted-N,N-dimethyltryptamines:: novel antagonists for the vascular 5-HT1B-like receptor [J].

Moloney, GP ;

Martin, GR ;

Mathews, N ;

MacLennan, S ;

Dodsworth, S ;

Sang, PY ;

Knight, C ;

Maxwell, M ;

Glen, RC .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (19) :2725-2733

[18] BROMINATED BIS(INDOLE) ALKALOIDS FROM THE MARINE SPONGE HEXADELLA SP [J].

MORRIS, SA ;

ANDERSEN, RJ .

TETRAHEDRON, 1990, 46 (03) :715-720

[19]

National Committee for Clinical Laboratory Standards (NCCLS), 1982, STAND METH DIL ANT S, P242

[20] Asymmetric multicomponent reactions (AMCRs):: The new frontier [J].

Ramón, DJ ;

Yus, M .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (11) :1602-1634

← 1 2 3 →