The microbiota and aging microenvironment in pancreatic cancer: Cell origin and fate

被引：7

作者：

Chen, Zhou ^{[1
,2
]}

Wang, Zhengfeng ^{[1
,2
]}

Du, Yan ^{[1
]}

Shi, Huaqing ^{[1
]}

Zhou, Wence ^{[1
,3
,4
]}

机构：

[1] Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China

[2] Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China

[3] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China

[4] Lanzhou Univ, Hosp 2, Clin Med Sch 1, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2022年 / 1877卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Cellular senescence; Microbiota; Pancreatic cancer; Tumor microenvironment; Targeted therapy; ONCOGENE-INDUCED SENESCENCE; NF-KAPPA-B; STELLATE CELLS; SECRETORY PHENOTYPE; GUT MICROBIOTA; IMMUNE SUPPRESSION; LIVER-CANCER; DNA; AGE; KRAS;

D O I：

10.1016/j.bbcan.2022.188826

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular senescence is a state of growth arrest where nonproliferative cells accumulate over time in the aging microenvironment under multiple external factors. Senescent cells exert a double-edged sword effect in an autocrine or paracrine manner: physiologically, they contribute to tissue development, prevent the multiplication of damaged cells and contribute to tissue repair and tumor suppression while favoring the onset of agerelated diseases, including tumors. The microbiota in human tissues is intricately linked to cellular senescence and is reportedly present in the tissues of various tumors (including pancreatic tumors), closely associated with tumorigenesis and progression. The microbiota can induce cells to undergo senescence, and their long-term effects can assist senescent cells in transforming and successfully escaping senescence, contributing to tumorigenesis and progression. Here, we focus on the correlation between the microbiota, cellular senescence, and pancreatic cancer to provide novel ideas for the study and therapy of pancreatic cancer.

引用

页数：14

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