Biomarkers of exposure, effect, and susceptibility in workers exposed to chloronitrobenzenes

被引：6

作者：

Sabbioni, Gabriele ^{[1
,2
]}

Norppa, Hannu ^{[3
]}

Hirvonen, Ari ^{[3
]}

Jarventaus, Hilkka ^{[3
]}

Jones, Christopher R. ^{[2
,4
]}

Yan, Huifang ^{[5
]}

Sepai, Ovnair ^{[4
]}

机构：

[1] Inst Environm & Occupat Toxicol, Casella Postale 108, CH-6780 Airolo, Switzerland

[2] Univ Munich, Walther Straub Inst Pharmakol & Toxikol, Munich, Germany

[3] Finnish Inst Occupat Hlth, Helsinki, Finland

[4] Newcastle Univ, Sch Med, Dept Environm & Occupat Med, Newcastle Upon Tyne, Tyne & Wear, England

[5] Chinese Acad Prevent Med, Inst Occupat Med, Beijing, Peoples R China

来源：

BIOMARKERS | 2016年 / 21卷 / 08期

关键词：

Biomonitoring; chloronitrobenzene; cytogenetic effects; hemoglobin adducts; polymorphism; urinary metabolites; GLUTATHIONE-S-TRANSFERASE; HEMOGLOBIN ADDUCTS; AROMATIC-AMINES; P-CHLORONITROBENZENE; URINARY METABOLITES; PROTEIN ADDUCTS; ARYLAMINES; RISK; 2,4,6-TRINITROTOLUENE; NITROBENZENE;

D O I：

10.3109/1354750X.2016.1172116

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biomonitoring methods were applied to workers exposed to high levels of chloronitrobenzenes. The external dose, internal dose, biologically effective dose, and biological effects were determined. Individual susceptibility was assessed by analyzing genetic polymorphisms of glutathione S-transferases M1, P1 and T1, and N-acetyltransferases 1 and 2. When the markers of exposure and susceptibility were compared with the frequency of chromosomal aberrations, clinical blood and urine parameters, and health effects typical of chloronitrobenzenes exposure, only a few of the comparisons were statistically significant. A statistically significantly higher frequency of chromosomal aberrations was detected in workers with a high level of hemoglobin-adducts.

引用

页码：721 / 730

页数：10

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