Interpenetrating biopolymer network based hydrogels for an effective drug delivery system

被引：53
作者：
Vashist, Arti [1 ]
Gupta, Y. K. [2 ]
Ahmad, Sharif [1 ]
机构：
[1] Jamia Millia Islamia, Dept Chem, Mat Res Lab, New Delhi 110025, India
[2] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India
来源：
CARBOHYDRATE POLYMERS | 2012年 / 87卷 / 02期
关键词：
Hydrogels; Drug delivery; Biopolymers; Chitosan; Degradation; CHITOSAN-BASED HYDROGELS; COMPATIBILITY; LINSEED; EPOXY;
D O I：
10.1016/j.carbpol.2011.09.030
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Discovery of hydrogels has resulted in developing competent controlled-release drug delivery systems. Present study describes the synthesis and characterization of novel pH responsive hydrogels of chitosan, hydroxyl ethyl cellulose (HEC) and polyol prepared by physical blending of the three components in different ratios. Vegetable oil derived polyol seems to act as a filler and cross linking agent. The synthesized hydrogels were characterized using FT-IR spectroscopy, thermo gravimetric analysis (TGA), Optical microscopy and scanning electron microscopy (SEM). Equilibrium swelling behavior of hydrogels in water and different buffers with pH values (2, 4, 7.3, and 8) indicated the sustained expansion of the films in different pH solutions. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1433 / 1439
页数：7
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