Synthesis of a-Amino Acid Amides: Ruthenium-Catalyzed Amination of a-Hydroxy Amides

被引：138

作者：

Zhang, Min ^{[1
]}

Imm, Sebastian ^{[1
]}

Baehn, Sebastian ^{[1
]}

Neumann, Helfried ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock EV, Inst Katalyse, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 47期

关键词：

amines; a-amino acid amides; a-hydroxy amides; homogeneous catalysis; ruthenium; N-ALKYLATION; BORROWING HYDROGEN; SECONDARY ALCOHOLS; AROMATIC-AMINES; SELECTIVE SYNTHESIS; EFFICIENT METHOD; TERTIARY-AMINES; COMPLEX; AMMONIA; DIAMINES;

D O I：

10.1002/anie.201104309

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Give me an N: The catalytic amination of α-hydroxy amides with a variety of amines, including anilines, primary and secondary aliphatic amines, and ammonia, yields a wide range of α-amino amides (see scheme). This atom-efficient amination protocol proceeds efficiently in the presence of a commercially available [Ru 3(CO) 12]/DCPE catalyst system. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11197 / 11201

页数：5

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