Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain

被引：18
作者：
El Daibani, Amal [1 ]
Che, Tao [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA
[2] Univ Hlth Sci & Pharm St Louis, Ctr Clin Pharmacol, St Louis, MO 63110 USA
来源：
MOLECULES | 2022年 / 27卷 / 03期
关键词：
nociceptin; orphanin FQ receptor; NOP receptor; ligands; opioid receptor; N; OFQ; analgesia; CENTRAL-NERVOUS-SYSTEM; KAPPA-OPIOID RECEPTOR; ORPHANIN-FQ; ORL1; RECEPTOR; TISSUE DISTRIBUTION; PHARMACOLOGICAL CHARACTERIZATION; ANTINOCICEPTIVE ACTION; SELECTIVE ANTAGONIST; NOP AGONIST; IN-VITRO;
D O I：
10.3390/molecules27030595
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In our society today, pain has become a main source of strain on most individuals. It is crucial to develop novel treatments against pain while focusing on decreasing their adverse effects. Throughout the extent of development for new pain therapies, the nociceptin/orphanin FQ receptor (NOP receptor) has appeared to be an encouraging focal point. Concentrating on NOP receptor to treat chronic pain with limited range of unwanted effects serves as a suitable alternative to prototypical opioid morphine that could potentially lead to life-threatening effects caused by respiratory depression in overdose, as well as generate abuse and addiction. In addition to these harmful effects, the uprising opioid epidemic is responsible for becoming one of the most disastrous public health issues in the US. In this article, the contributing molecular and cellular structure in controlling the cellular trafficking of NOP receptor and studies that support the role of NOP receptor and its ligands in pain management are reviewed.
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页数：18
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