In Vitro and In Vivo Anti-Helicobacter pylori Activity of Probiotics Isolated from Mongolian Dairy Products

被引：3

作者：

Takeda, Shiro ^{[1
]}

Takeshita, Masahiko ^{[1
]}

Matsusaki, Tastuya ^{[1
]}

Kikuchi, Yukiharu ^{[1
]}

Tsend-ayush, Chuluunbat ^{[2
]}

Oyunsuren, Tsendesuren ^{[3
]}

Miyata, Masahiko ^{[4
]}

Maeda, Ken ^{[4
]}

Yasuda, Shin ^{[4
]}

Aiba, Yuji ^{[5
]}

Koga, Yasuhiro ^{[5
]}

Igoshi, Keiji ^{[4
]}

机构：

[1] Minami Nihon Rakuno Kyodo Co Ltd, Div Res & Dev, Miyakonojo, Miyazaki 8850003, Japan

[2] Mongolian Univ Sci & Technol, Food & Biotechnol Sch, Ulaanbaatar, Mongolia

[3] Mongolian Biotechnol Assoc, Ulaanbaatar, Mongolia

[4] Tokai Univ, Sch Agr, Dept Biosci, Aso, Kumamoto, Japan

[5] Tokai Univ, Sch Med, Infect Dis Lab, Isehara, Kanagawa 2591193, Japan

来源：

FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2015年 / 21卷 / 03期

关键词：

anti-Helicobacter pylori; probiotics; Lactobacillus paracasei; lactic acid; mongolian daily products; LACTOBACILLUS-GASSERI OLL2716; LACTIC-ACID BACTERIA; PREVENTION; INFECTION; ERADICATION; SUPPRESSION; INHIBITION; GROWTH; STRAIN;

D O I：

10.3136/fstr.21.399

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Helicobacter (H.) pylori is known to be a bacterial risk factor for gastric cancer. In this study, 16 strains of lactic acid bacteria (LAB) isolated from Mongolian dairy products were screened for potential probiotic activity against H. pylon strain no. 130 in vitro. Lactobacillus (L.) paracasei 06TCa19 and L. plantarum 07MR044 were identified as LAB strains with anti-H. pylori activities. Compared to strain 07MR044, strain 06TCa19 was more potent in reducing H. pylori counts in co-culture. The ability of strain 06TCa19 to inhibit the growth of H. pylori was attributable to its rapid and excessive generation of lactic acid. Moreover, oral administration of strain 06TCa19 was found to significantly reduce the number of colonizing H. pylori in the stomach of H. pylori strain no. 130-infected mice. Thus, strain 06TCa19 is potentially effective against H. pylori infection.

引用

页码：399 / 406

页数：8

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