Calcinosis cutis Part I. Diagnostic pathway

被引:202
作者
Reiter, Nadine [1 ]
El-Shabrawi, Laila [1 ]
Leinweber, Bernd [1 ]
Berghold, Andrea [2 ]
Aberer, Elisabeth [1 ]
机构
[1] Med Univ Graz, Dept Dermatol, A-8036 Graz, Austria
[2] Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria
关键词
calcinosis cutis; diagnosis; review; skin calcification; PORPHYRIA-CUTANEA-TARDA; EHLERS-DANLOS-SYNDROME; JUVENILE DERMATOMYOSITIS; SYSTEMIC-SCLEROSIS; LINEAR SCLERODERMA; RENAL-FAILURE; RISK-FACTORS; CALCIPHYLAXIS; CALCIFICATION; PATIENT;
D O I
10.1016/j.jaad.2010.08.038
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Calcinosis cutis is characterized by the deposition of insoluble calcium salts in the skin and subcutaneous tissue. The syndrome is separated into five subtypes: dystrophic calcification, metastatic calcification, idiopathic calcification, iatrogenic calcification, and calciphylaxis. Dystrophic calcification appears as a result of local tissue damage with normal calcium and phosphate levels in serum. Metastatic calcification is characterized by an abnormal calcium and/or phosphate metabolism, leading to the precipitation of calcium in cutaneous and subcutaneous tissue. idiopathic calcification occurs without any underlying tissue damage or metabolic disorder. Skin calcification in iatrogenic calcinosis cutis is a side effect of therapy. Calciphylaxis presents with small vessel calcification mainly affecting blood vessels of the dermis or subcutaneous fat. Disturbances in calcium and phosphate metabolism and hyperparathyroidism can be observed. (J Am Acad Dermatol 2011;65:1-12.)
引用
收藏
页码:1 / 12
页数:12
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