Impact of Magnetic Resonance Imaging on Cardiac Mortality in Thalassemia Major

被引：43

作者：

Chouliaras, Giorgos ^{[1
]}

Berdoukas, Vasilios ^{[1
]}

Ladis, Vassilis ^{[1
]}

Kattamis, Antonis ^{[1
]}

Chatziliami, Antonia

Fragodimitri, Christina

Karabatsos, Fotis

Youssef, Jacqueline

Karagiorga-Lagana, Markissia

机构：

[1] Univ Athens, Thalassaemia Unit, Dept Paediat 1, Aghia Sophia Childrens Hosp, Athens 11527, Greece

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2011年 / 34卷 / 01期

关键词：

thalassemia major; cardiac death; magnetic resonance imaging (MRI); iron overload; iron chelation therapy; MYOCARDIAL IRON; COMBINED THERAPY; HEART-FAILURE; DEFEROXAMINE; DEFERIPRONE; SURVIVAL; COMPLICATIONS; TRANSFUSION; MORBIDITY; REGIMES;

D O I：

10.1002/jmri.22621

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To evaluate whether the introduction of magnetic resonance imaging (MRI) in the management of thalassemia major (TM) patients has affected the risk of cardiac death. Materials and Methods: In all, 804 TM patients from two large reference units were included and the risk of dying of cardiac causes, before and after their first MRI, was assessed by a Cox proportional hazards model with time-dependent covariates. Results: Adding information from MRI reduced the risk of cardiac death from 6.0 deaths/1000 patient-years to 3.9 deaths/1000 patient-years (P = 0.22). The risk of cardiac death before having an MRI study was 82% higher compared to the risk observed after the first MRI. Conclusion: MRI has become a vital component of ongoing management and seems to have a beneficial effect on cardiac mortality in TM.

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收藏

页码：56 / 59

页数：4

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