Impact of Magnetic Resonance Imaging on Cardiac Mortality in Thalassemia Major

被引：42
|
作者：
Chouliaras, Giorgos [1 ]
Berdoukas, Vasilios [1 ]
Ladis, Vassilis [1 ]
Kattamis, Antonis [1 ]
Chatziliami, Antonia
Fragodimitri, Christina
Karabatsos, Fotis
Youssef, Jacqueline
Karagiorga-Lagana, Markissia
机构：
[1] Univ Athens, Thalassaemia Unit, Dept Paediat 1, Aghia Sophia Childrens Hosp, Athens 11527, Greece
来源：
JOURNAL OF MAGNETIC RESONANCE IMAGING | 2011年 / 34卷 / 01期
关键词：
thalassemia major; cardiac death; magnetic resonance imaging (MRI); iron overload; iron chelation therapy; MYOCARDIAL IRON; COMBINED THERAPY; HEART-FAILURE; DEFEROXAMINE; DEFERIPRONE; SURVIVAL; COMPLICATIONS; TRANSFUSION; MORBIDITY; REGIMES;
D O I：
10.1002/jmri.22621
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose: To evaluate whether the introduction of magnetic resonance imaging (MRI) in the management of thalassemia major (TM) patients has affected the risk of cardiac death. Materials and Methods: In all, 804 TM patients from two large reference units were included and the risk of dying of cardiac causes, before and after their first MRI, was assessed by a Cox proportional hazards model with time-dependent covariates. Results: Adding information from MRI reduced the risk of cardiac death from 6.0 deaths/1000 patient-years to 3.9 deaths/1000 patient-years (P = 0.22). The risk of cardiac death before having an MRI study was 82% higher compared to the risk observed after the first MRI. Conclusion: MRI has become a vital component of ongoing management and seems to have a beneficial effect on cardiac mortality in TM.
引用
收藏
页码：56 / 59
页数：4
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