Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus

被引：40

作者：

Duarte, Ana M. ^{[1
]}

Guarino, Maria P. ^{[2
]}

Barroso, Sonia ^{[1
]}

Gil, Maria M. ^{[1
]}

机构：

[1] Politecn Leiria, MARE Marine & Environm Sci Ctr, P-2520630 Peniche, Portugal

[2] Politecn Leiria, CiTechCare Ctr Innovat Care & Hlth Technol, P-2410541 Leiria, Portugal

来源：

FOODS | 2020年 / 9卷 / 03期

关键词：

type 2 diabetes mellitus; phytopharmacology; dipeptidyl peptidase-4 (DPP4); alpha-amylase; alpha-glucosidase; lipase; protein tyrosine phosphatase 1B (PTP1B); DIPEPTIDYL-PEPTIDASE-IV; LIPASE INHIBITING ACTIVITIES; POTENT ALPHA-GLUCOSIDASE; PANCREATIC LIPASE; IN-VITRO; PHENOLIC-COMPOUNDS; MAGNETIC NANOPARTICLES; BIOACTIVE COMPOUNDS; DIETARY PROTEINS; BROWN-ALGAE;

D O I：

10.3390/foods9030271

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Type 2 Diabetes Mellitus (T2DM) is a chronic disease which corresponds to 90% of the worldwide cases of diabetes, mainly due to epigenetic factors such as unhealthy lifestyles. First line therapeutic approaches are based on lifestyle changes, most of the time complemented with medication mostly associated with several side effects and high costs. As a result, the scientific community is constantly working for the discovery and development of natural therapeutic strategies that provide lower financial impact and minimize side effects. This review focus on these nature-based therapeutic strategies for prevention and control of T2DM, with a special emphasis on natural compounds that present pharmacological activity as dipeptidyl peptidase-4 (DPP4), alpha-amylase, alpha-glucosidase, lipase, and protein tyrosine phosphatase 1B (PTP1B) inhibitors.

引用

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