New mechanisms and functions of actin nucleation

被引：155

作者：

Firat-Karalar, Elif Nur ^{[1
]}

Welch, Matthew D. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 01期

关键词：

ARP2/3; COMPLEX; FILOPODIA FORMATION; CONTRACTILE RING; WAVE-COMPLEX; FORMIN; PROTEIN; SPIRE; WASH; POLYMERIZATION; MOTILITY;

D O I：

10.1016/j.ceb.2010.10.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In cells the de novo nucleation of actin filaments from monomers requires actin-nucleating proteins. These fall into three main families - the Arp2/3 complex and its nucleation promoting factors (NPFs), formins, and tandem-monomer-binding nucleators. In this review, we highlight recent advances in understanding the molecular mechanism of actin nucleation by both well-characterized and newly identified nucleators, and explore current insights into their cellular functions in membrane trafficking, cell migration and division. The mechanisms and functions of actin nucleators are proving to be more complex than previously considered, with extensive cooperation and overlap in their cellular roles.

引用

页码：4 / 13

页数：10

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