TMPRSS2, a novel host-directed drug target against SARS-CoV-2

被引：11
作者：
Keller, Christian [1 ]
Boettcher-Friebertshauser, Eva [1 ]
Lohoff, Michael [2 ]
机构：
[1] Philipps Univ Marburg, Inst Virol, Marburg, Germany
[2] Philipps Univ Marburg, Inst Med Microbiol & Hyg, Marburg, Germany
来源：
SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2022年 / 7卷 / 01期
关键词：
D O I：
10.1038/s41392-022-01084-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
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页数：3
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[1]   TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells [J].
Bestle, Dorothea ;
Heindl, Miriam Ruth ;
Limburg, Hannah ;
Thuy Van Lam Van ;
Pilgram, Oliver ;
Moulton, Hong ;
Stein, David A. ;
Hardes, Kornelia ;
Eickmann, Markus ;
Dolnik, Olga ;
Rohde, Cornelius ;
Klenk, Hans-Dieter ;
Garten, Wolfgang ;
Steinmetzer, Torsten ;
Boettcher-Friebertshaeuser, Eva .
LIFE SCIENCE ALLIANCE, 2020, 3 (09)
[2]   Aprotinin treatment against SARS-CoV-2: A randomized phase III study to evaluate the safety and efficacy of a pan-protease inhibitor for moderate COVID-19 [J].
Javier Redondo-Calvo, Francisco ;
Fernando Padin, Juan ;
Ramon Munoz-Rodriguez, Jose ;
Serrano-Oviedo, Leticia ;
Lopez-Juarez, Pilar ;
Porras Leal, Maria Lourdes ;
Gonzalez Gasca, Francisco Javier ;
Rodriguez Martinez, Marta ;
Perez Serrano, Raul ;
Sanchez Cadena, Abraham ;
Bejarano-Ramirez, Natalia ;
Munoz Hornero, Constanza ;
Barbera Farre, Jose Ramon ;
Dominguez-Quesada, Inmaculada ;
Sepulveda Berrocal, Maria A. ;
Villegas Fernandez-Infantes, Maria Dolores ;
Manrique Romo, Maria Isabel ;
Parra Comino, Angel ;
Manuel Perez-Ortiz, Jose ;
Javier Gomez-Romero, Francisco .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2022, 52 (06)
[3]   Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose of BNT162b2 vaccine in previously unresponsive older adults [J].
Romero-Olmedo, Addi J. ;
Schulz, Axel Ronald ;
Hochstaetter, Svenja ;
Das Gupta, Dennis ;
Virta, Iiris ;
Hirseland, Heike ;
Staudenraus, Daniel ;
Camara, Barbel ;
Muench, Carina ;
Hefter, Veronique ;
Sapre, Siddhesh ;
Kraehling, Verena ;
Mueller-Kraeuter, Helena ;
Widera, Marek ;
Mei, Henrik E. ;
Keller, Christian ;
Lohoff, Michael .
NATURE MICROBIOLOGY, 2022, 7 (02) :195-+
[4]   A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic [J].
Shapira, Tirosh ;
Monreal, I. Abrrey ;
Dion, Sebastien P. ;
Buchholz, David W. ;
Imbiakha, Brian ;
Olmstead, Andrea D. ;
Jager, Mason ;
Desilets, Antoine ;
Gao, Guang ;
Martins, Mathias ;
Vandal, Thierry ;
Thompson, Connor A. H. ;
Chin, Aaleigha ;
Rees, William D. ;
Steiner, Theodore ;
Nabi, Ivan Robert ;
Marsault, Eric ;
Sahler, Julie ;
Diel, Diego G. ;
Van de Walle, Gerlinde R. ;
August, Avery ;
Whittaker, Gary R. ;
Boudreault, Pierre-Luc ;
Leduc, Richard ;
Aguilar, Hector C. ;
Jean, Francois .
NATURE, 2022, 605 (7909) :340-+
[5]   Nafamostat in hospitalized patients with moderate to severe COVID-19 pneumonia: a randomised Phase II clinical trial [J].
Zhuravel, Sergey, V ;
Khmelnitskiy, Oleg K. ;
Burlaka, Oleg O. ;
Gritsan, Alexey, I ;
Goloshchekin, Boris M. ;
Kim, Seieun ;
Hong, Ka Young .
ECLINICALMEDICINE, 2021, 41
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