Inflammatory Markers and Cytokines in Moderate and Critical Cases of COVID-19

被引：13

作者：

Chang, Soon Hee ^{[1
]}

Minn, Dohsik ^{[2
]}

Kim, Shin-Woo ^{[3
]}

Kim, Yu Kyung ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea

[2] Seegene Med Fdn, Dept Diagnost Immunol, Seoul, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea

来源：

CLINICAL LABORATORY | 2021年 / 67卷 / 09期

关键词：

COVID-19; inflammatory marker; cytokine; interleukin-6; severity; SEVERITY; INTERLEUKIN-6;

D O I：

10.7754/Clin.Lab.2021.210142

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Inflammatory responses have been suggested to be associated with coronavirus disease 2019 (COVID-19). This study investigated the inflammatory markers and cytokines in COVID-19 according to its severity. Methods: We enrolled 49 patients with COVID-19, who were classified as either moderate or critical cases. Serum or plasma interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels were measured. Results: Lactate dehydrogenase, ferritin, C-reactive protein, and procalcitonin levels were significantly higher in the critical group than in the moderate group (p < 0.001). IL-6 and TNF-alpha levels were significantly higher in the critical group, with elevated IL-6 levels from the first to third weeks after confirmed PCR (p < 0.05). Conclusions: Inflammatory markers and cytokines were increased in COVID-19 and closely related to the severity of the disease. We recommend early active monitoring of IL-6 levels along with inflammatory markers for severe COVID-19.

引用

页码：2115 / 2120

页数：6

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