Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential in Hematology and Cardiovascular Disease

被引:9
作者
Hoermann, Gregor [1 ]
机构
[1] MLL Munich Leukemia Lab, D-81377 Munich, Germany
关键词
clonal hematopoiesis of indeterminate potential; clonal cytopenia of unknown significance; myeloid neoplasms; cardiovascular risk; cell-free DNA; C-REACTIVE PROTEIN; CELL-FREE DNA; MUTATIONS; RISK; CANCER; ATHEROSCLEROSIS; PLASMA; ASSOCIATION; INSIGHTS; PATIENT;
D O I
10.3390/diagnostics12071613
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal hematopoiesis of indeterminate potential (CHIP). CHIP-mutations can be found in the cell-free DNA (cfDNA) of plasma, are a potential cause of false positive results in liquid profiling, and thus limit its usage in screening settings. Various strategies are in place to mitigate the effect of CHIP on the performance of ctDNA assays, but the detection of CHIP also represents a clinically significant incidental finding. The sequelae of CHIP comprise the risk of progression to a hematologic neoplasm including therapy-related myeloid neoplasms. While the hematological risk increases with the co-occurrence of unexplained blood count abnormalities, a number of non-hematologic diseases have independently been associated with CHIP. In particular, CHIP represents a major risk factor for cardiovascular disease such as atherosclerosis or heart failure. The management of CHIP requires an interdisciplinary setting and represents a new topic in the field of cardio-oncology. In the future, the information on CHIP may be taken into account for personalized therapy of cancer patients.
引用
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页数:13
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