Electrochemical oxidative synthesis of 2-benzoylquinazolin-4(3H)-one via C(sp3)-H amination under metal-free conditions

被引：9

作者：

Hu, Yongzhi ^{[1
]}

Ma, Xinhua ^{[1
]}

Hou, Huiqing ^{[1
]}

Sun, Weiming ^{[1
]}

Tu, Shuqing ^{[2
]}

Wu, Mei ^{[1
]}

Lin, Rongkun ^{[1
]}

Xu, Xiuzhi ^{[1
]}

Ke, Fang ^{[1
]}

机构：

[1] Fujian Med Univ, Sch Pharm, Fujian Prov Key Lab Nat Med Pharmacol, Fuzhou 350004, Peoples R China

[2] Fujian Med Univ, Fujian Matern & Child Hlth Hosp, Affiliated Hosp, Fuzhou 350000, Peoples R China

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2021年 / 11卷 / 19期

关键词：

C-H AMINATION; RADICAL-ADDITION; IODINE; FUNCTIONALIZATION; QUINAZOLINONES; AMIDATION; BONDS; ACYLATION; KETONES; AMINES;

D O I：

10.1039/d1cy01230d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An electrochemically induced C(sp(3))-H amination of 2-aminobenzamides with ketones using TBAI as a catalyst was developed, and provided 2-benzoylquinazolin-4(3H)-ones under metal-free conditions. The reaction proceeded using the relatively low-toxicity methanol as the solvent, employed molecular oxygen as the ideal green oxidant in a simple undivided cell, and exhibited high atom economy. The mechanism of this C(sp(3))-H amination strategy was concluded to involve generation of an acetophenone radical, and its easy further oxidation to form 2-oxo-2-phenylacetaldehyde.

引用

页码：6374 / 6379

页数：6

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