Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells

被引：30

作者：

Zhou, Gui-Sheng ^{[2
,3
]}

Hu, Zheng ^{[2
]}

Fang, Hai-Tong ^{[2
]}

Zhang, Feng-Xiang ^{[2
]}

Pan, Xiao-Fen ^{[2
]}

Chen, Xiao-Qin ^{[4
]}

Hu, An-Mei ^{[5
]}

Xu, Ling ^{[6
]}

Zhou, Guang-Biao ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Lab Mol Carcinogenesis & Targeted Therapy Canc, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Lab Mol Carcinogenesis & Targeted Therapy Canc, Guangzhou Inst Biomed & Hlth, Beijing 100101, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China

[4] Sun Yat Sen Univ, Canc Hosp, Dept Hematol, Guangzhou 510275, Guangdong, Peoples R China

[5] Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China

[6] Sun Yat Sen Univ, Affiliated Hosp 2, Guangzhou 510275, Guangdong, Peoples R China

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Triptolide; Acute myeloid leukemia (AML); t(8; 21); AML1-ETO; C-KIT; JAK-STAT; NF-kappa B; KAPPA-B ACTIVATION; BREAST-CANCER CELLS; TRIPTERYGIUM-WILFORDII; PROMYELOCYTIC LEUKEMIA; PANCREATIC-CANCER; INDUCED APOPTOSIS; AML1-ETO; EXPRESSION; KIT; LEUKEMOGENESIS;

D O I：

10.1016/j.leukres.2010.07.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Triptolide is a compound isolated from the traditional Chinese medicinal herb Tripterygium wilfordii that shows potent anti-tumor activities, but its effects on acute myeloid leukemia with t(8;21) remain unclear. Here we report that triptolide inhibits cell proliferation and induces apoptosis in a dose- and time-dependent manner of t(8;21)-bearing Kasumi-1, SKNO-1 and CD34+ cells harvested from bone marrow samples of patients with t(8;21) leukemia. We show that triptolide triggers cleavage of the resultant AML1-ETO fusion protein of t(8;21), and causes downregulation of C-KIT followed by inhibition of JAK-STAT signaling. Triptolide downregulates p65 and inhibits the DNA-binding activity of NF-kappa B. Our data indicate that triptolide might be an effective agent for t(8;21) leukemia. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：214 / 218

页数：5

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