Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

被引：59
作者：
Keir, Lindsay [3 ]
Coward, Richard J. M. [1 ,2 ]
机构：
[1] Univ Bristol, Acad & Childrens Renal Unit, Bristol, Avon, England
[2] Bristol Royal Hosp Children, Bristol, Avon, England
[3] Royal Hosp Sick Children, Dept Med Pediat, Glasgow G3 8SJ, Lanark, Scotland
来源：
PEDIATRIC NEPHROLOGY | 2011年 / 26卷 / 04期
基金：
英国医学研究理事会;
关键词：
Haemolytic uraemic syndrome; Thrombotic microangiopathy; Endothelial cell; Podocyte; VEGF-A; HEMOLYTIC-UREMIC SYNDROME; COMPLEMENT FACTOR-H; SHIGA-TOXIN; ESCHERICHIA-COLI; MUTATIONS; EXPRESSION; BINDING; PREDISPOSE; ADAMTS13; KIDNEYS;
D O I：
10.1007/s00467-010-1637-4
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).
引用
收藏
页码：523 / 533
页数：11
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