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A Peculiar Case of Pneumonia due to Mycoplasma pneumoniae in a Child with Cystic Fibrosis and Sensibilization to Aspergillus fumigatus
被引:3
|作者:
Peccini, Laura
[1
]
Pennoni, Serena
[1
]
Mencarini, Valeria
[2
]
Saponara, Marco
[1
]
Palladino, Nicola
[2
]
Principi, Nicola
[3
]
Pennoni, Guido
[2
]
Esposito, Susanna
[4
]
机构:
[1] Univ Perugia, Dept Surg & Biomed Sci, Pediat Clin, I-06132 Perugia, Italy
[2] Branca Hosp, Cyst Fibrosis Ctr Umbria Reg, I-06020 Branca, Italy
[3] Univ Milan, I-20122 Milan, Italy
[4] Univ Parma, Dept Med & Surg, Pediat Clin, Pietro Barilla Childrens Hosp, Via Gramsci 14, I-43126 Parma, Italy
来源:
PATHOGENS
|
2020年
/
9卷
/
01期
关键词:
allergic bronchopulmonary aspergillosis;
antimicrobial resistance;
Aspergillus fumigatus;
cystic fibrosis;
pneumonia;
ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS;
D O I:
10.3390/pathogens9010015
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Aspergillus fumigatus plays a major role in pulmonary exacerbations in patients with cystic fibrosis. The most common A. fumigatus diseases are those based on immune-mediated response to A. fumigatus antigens; including allergic bronchopulmonary aspergillosis (ABPA). In this condition; the presence of A. fumigatus in the lower respiratory tract triggers an IgE-mediated hypersensitivity response that causes airway inflammation; bronchospasms; and bronchiectasis. This case report describes a ten-year-old male patient suffering from cystic fibrosis (CF) in whom the diagnosis of ABPA occurred in association with pneumonia due to Mycoplasma pneumoniae more than two weeks after hospitalization. This case is a good example of how difficult the identification of ABPA in CF patients can be and highlights that ABPA can occur in association with co-infections due to other pathogens. In order to avoid the risk of a late ABPA diagnosis, it is imperative that the diagnostic criteria guidelines are reviewed and standardized.
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