In vitro and in vivo studies on biodegradable magnesium alloy

被引：45

作者：

Hou, Lida ^{[1
]}

Li, Zhen ^{[1
]}

Pan, Yu ^{[1
]}

Du, Li ^{[1
]}

Li, Xinlin ^{[1
]}

Zheng, Yufeng ^{[1
,2
]}

Li, Li ^{[1
]}

机构：

[1] Harbin Engn Univ, Ctr Biomed Mat & Engn, Harbin 150001, Peoples R China

[2] Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China

来源：

PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL | 2014年 / 24卷 / 05期

基金：

国家高技术研究发展计划(863计划);

关键词：

Magnesium alloy; Extrusion; Performance; Biocompatibility; CORROSION; APATITE; METAL;

D O I：

10.1016/j.pnsc.2014.09.002

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The microstructure, mechanical property, electrochemical behavior and biocompatibility of magnesium alloy (BioDe MSM (TM)) were studied in the present work. The experimental results demonstrated that grain refining induced by extrusion improves the alloy strength significantly from 162 MPa for the as-cast alloy to 241 MPa for the as-extruded one. The anticorrosion properties of the as-extruded alloy also increased. Furthermore, the hemolysis ratio was decreased from 4.7% for the as-cast alloy to 2.9% for the as-extruded one, both below 5%. BioDe MSM (TM) alloy shows good biocompatibility after being implanted into the dorsal muscle and the femoral shaft of the New Zealand rabbit, respectively, and there are no abnormalities after short-term implantation. In vivo observation indicated that the corrosion rate of this alloy varies with different implantation positions, with higher degradation rate in the femur than in the muscle. (C) 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：466 / 471

页数：6

共 30 条

[1]

[Anonymous], INT J ORTHOPAEDICS

[2] Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation:: a review [J].

Böstman, O ;

Pihlajamäki, H .

BIOMATERIALS, 2000, 21 (24) :2615-2621

[3]

[高家诚 Gao Jiacheng], 2012, [功能材料, Journal of Functional Materials], V43, P2577

[4] Wear particles, periprosthetic osteolysis and the immune system [J].

Goodman, Stuart B. .

BIOMATERIALS, 2007, 28 (34) :5044-5048

[5]

Hang B.Y., 2009, NONFERROUS METALS MA

[6] Role of magnesium in genomic stability [J].

Hartwig, A .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 475 (1-2) :113-121

[7]

Hermawan H., 2011, MAT RES A, V93, P1

[8] Biomaterials in total joint replacement [J].

Katti, KS .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2004, 39 (03) :133-142

[9] A scale of metal ion binding strengths correlating with ionic charge, Pauling electronegativity, toxicity, and other physiological effects [J].

Kinraide, Thomas B. ;

Yermiyahu, Uri .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (09) :1201-1213

[10] Precipitation of magnesium apatite on pure magnesium surface during immersing in Hank's solution [J].

Kuwahara, H ;

Al-Abdullat, Y ;

Mazaki, N ;

Tsutsumi, S ;

Aizawa, T .

MATERIALS TRANSACTIONS, 2001, 42 (07) :1317-1321

← 1 2 3 →