Antibiotic tolerance induced by lactoferrin in clinical Pseudomonas aeruginosa isolates from cystic fibrosis patients

被引：11
作者：
Andrés, MT
Viejo-Diaz, M
Pérez, F
Fierro, JF
机构：
[1] Univ Oviedo, Fac Med, Dept Funct Biol Microbiol, Oviedo 33006, Spain
[2] Univ Oviedo, Lab Oral Microbiol, Sch Stomatol, Oviedo 33006, Spain
[3] Hosp Cent Asturias, Dept Microbiol 1, Oviedo, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期
关键词：
D O I：
10.1128/AAC.49.4.1613-1616.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginusa isolates from cystic fibrosis patients showed higher ATE values (<= 6-fold) than other clinical strains.
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页码：1613 / 1616
页数：4
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