Focal adhesion kinase: An essential kinase in the regulation of cardiovascular functions

被引：34
|
作者：
Vadali, Kavita
Cai, Xinming
Schaller, Michael D.
机构：
[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Chapel Hill, NC 27599 USA
来源：
IUBMB LIFE | 2007年 / 59卷 / 11期
关键词：
FAK; tyrosine kinase; proliferation; mechanical signaling; apoptosis; protein function; signal transduction;
D O I：
10.1080/15216540701694245
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies using animal models have demonstrated an important role for FAK in the cardiovascular system. In particular, FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice. FAK function at the cellular level is discussed to provide insight into the mechanisms regulating these biological events and the role of FAK in controlling endothelial junctions and responses to mechanical stimulation are discussed.
引用
收藏
页码：709 / 716
页数：8
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