Focal adhesion kinase: An essential kinase in the regulation of cardiovascular functions

被引：35
作者：
Vadali, Kavita
Cai, Xinming
Schaller, Michael D.
机构：
[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Chapel Hill, NC 27599 USA
来源：
IUBMB LIFE | 2007年 / 59卷 / 11期
关键词：
FAK; tyrosine kinase; proliferation; mechanical signaling; apoptosis; protein function; signal transduction;
D O I：
10.1080/15216540701694245
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies using animal models have demonstrated an important role for FAK in the cardiovascular system. In particular, FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice. FAK function at the cellular level is discussed to provide insight into the mechanisms regulating these biological events and the role of FAK in controlling endothelial junctions and responses to mechanical stimulation are discussed.
引用
收藏
页码：709 / 716
页数：8
相关论文
共 59 条
[1]   Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants [J].
Ali, Mir H. ;
Mungai, Paul T. ;
Schumacker, Paul T. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 291 (01) :L38-L45
[2]   Matrix survival signaling:: From fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase [J].
Almeida, EAC ;
Ilic, D ;
Han, Q ;
Hauck, CR ;
Jin, F ;
Kawakatsu, H ;
Schlaepfer, DD ;
Damsky, CH .
JOURNAL OF CELL BIOLOGY, 2000, 149 (03) :741-754
[3]  
Angelucci A, 2007, CURR PHARM DESIGN, V13, P2129
[4]   FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase [J].
Bellas, RE ;
Harrington, EO ;
Sheahan, KL ;
Newton, J ;
Marcus, C ;
Rounds, S .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 282 (05) :L1135-L1142
[5]   Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability - A novel mechanism regulating smooth muscle cell proliferation [J].
Bond, M ;
Sala-Newby, GB ;
Newby, AC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (36) :37304-37310
[6]   Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation [J].
Braren, R ;
Hu, HQ ;
Kim, YH ;
Beggs, HE ;
Reichardt, LF ;
Wang, R .
JOURNAL OF CELL BIOLOGY, 2006, 172 (01) :151-162
[7]   Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp-2-dependent and -independent mechanisms [J].
Bryant, Patrick ;
Zheng, Qingxia ;
Pumiglia, Kevin .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (11) :4201-4213
[8]   A novel role for FAK as a protease-targeting adaptor protein: Regulation by p42 ERK and Src [J].
Carragher, NO ;
Westhoff, MA ;
Fincham, VJ ;
Schaller, MD ;
Frame, MC .
CURRENT BIOLOGY, 2003, 13 (16) :1442-1450
[9]   Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 [J].
Cascone, I ;
Napione, L ;
Maniero, F ;
Serini, G ;
Bussolino, F .
JOURNAL OF CELL BIOLOGY, 2005, 170 (06) :993-1004
[10]   Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy [J].
DiMichele, Laura A. ;
Doherty, Jason T. ;
Rojas, Mauricio ;
Beggs, Hilary E. ;
Reichardt, Louis F. ;
Mack, Christopher P. ;
Taylor, Joan M. .
CIRCULATION RESEARCH, 2006, 99 (06) :636-645
123456