Repetitive oocyte donation does not decrease serum anti-Mullerian hormone levels

Objective: To determine if the anti-Mullerian hormone (AMH), a proposed marker of ovarian aging, decreases with repetitive oocyte donation. Design: Retrospective cohort. Setting: Academic. Patient(s): Thirty-six young women who underwent three to seven oocyte donation cycles. Intervention(s): Assessor blind determination of AMH levels from serum samples collected during each treatment cycle. Main Outcome Measure(s): Cycle trends of serum AMH levels. Result(s): The AMH was the only predictor of oocyte yield in the first cycles. The AMH was negatively associated with donor age and follicle stimulating hormone (FSH) dose used. Serum AMH levels did not show any decrease per treatment cycle basis and per maximum number of oocyte donation cycles performed per woman. Whereas donors who underwent six cycles showed increasing AMH levels when controlled for studied covariates, the slopes of the multiple regression curves were not significantly different from donors who underwent three, four, and five cycles. Clinical outcome assessed by FSH dose/number of oocytes ratio did not show significant change over repetitive cycles. Intercycle variation of AMH in all patients over three cycles was found to be 12.5%, which was within the reported intermenstrual range. Conclusion(s): Serum AMH levels do not decrease over repetitive oocyte donation cycles, which may imply that accelerated ovarian aging may not occur in oocyte donors. (Fertil Steril (R) 2010; 94: 905-12. (c) 2010 by American Society for Reproductive Medicine.)