Electrophoretic pattern of glutathione S-transferase (GST) in antibiotic resistance Gram-positive bacteria from poultry litter

被引：20

作者：

Pugazhendhi, Arivalagan ^{[1
]}

Dhanarani, Sridevi ^{[2
]}

Shankar, Congeevaram ^{[3
]}

Prakash, Piruthiviraj ^{[4
]}

Ranganathan, Kuppusamy ^{[5
]}

Saratale, Rijuta Ganesh ^{[6
]}

Thamaraiselvi, Kaliannan ^{[2
]}

机构：

[1] Ton Duc Thang Univ, Fac Environm & Labour Safety, Ho Chi Minh City, Vietnam

[2] Bharathidasan Univ, Dept Environm Biotechnol, Lab Mol Bioremediat & Nanobiotechnol, Tiruchirappalli 620024, Tamil Nadu, India

[3] Ind Waste Management Assoc, Madras 600083, Tamil Nadu, India

[4] DRDO BU, Bharathiar Univ Campus, Coimbatore 614046, Tamil Nadu, India

[5] Cent Pollut Control Board, New Delhi 110032, India

[6] Dongguk Univ Seoul, Res Inst Biotechnol & Med Converged Sci, Goyang Si 10326, Gyeonggido, South Korea

来源：

MICROBIAL PATHOGENESIS | 2017年 / 110卷

关键词：

Glutathione S-transferase (GST); Antibiotics Poultry litter; Isozyme; Resistant bacteria; PROTEIN; PURIFICATION; ISOENZYMES; IDENTIFICATION; EXPRESSION; ENZYMES; STRESS;

D O I：

10.1016/j.micpath.2017.07.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study is aimed to assess the role of glutathione S-transferase (GST) in antibiotic resistance among the bacteria isolated from the poultry litter and to identify the effect of GST to reduce the antimicrobial activity of antibiotics. Induction of various antibiotics to Staphylococcus, Streptococcus and Micrococcus sp. isolated from the poultry litter showed that the activity of GST was three to four folds higher than those of control. Analysis of the isozyme pattern of GST revealed that variation in the expression may be due to antibiotic resistance. The results concluded that GST might play an important role in the protection against the toxic effect of the antimicrobial agents which leads bacteria to become resistant to antibiotics. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：285 / 290

页数：6

共 39 条

[1] Proteus mirabilis glutathione S-transferase B1-1 is involved in protective mechanisms against oxidative and chemical stresses [J].