The Ultimaster Biodegradable-Polymer Sirolimus-Eluting Stent: An Updated Review of Clinical Evidence

被引：42

作者：

Chisari, Alberto ^{[1
]}

Pistritto, Anna Maria ^{[2
]}

Piccolo, Raffaele ^{[3
]}

La Manna, Alessio ^{[4
]}

Danzi, Gian Battista ^{[1
]}

机构：

[1] Santa Corona Hosp, Div Cardiol, Via 25 Aprile 38, I-17027 Pietra Ligure, Italy

[2] San Paolo Hosp, Div Cardiol, I-17100 Savona, Italy

[3] Univ Bern, Univ Hosp Bern, Dept Cardiol, CH-3010 Bern, Switzerland

[4] Univ Catania, Ferrarotto Hosp, Cardiovasc Dept, I-95124 Catania, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 09期

关键词：

Ultimaster stent; biodegradable polymer drug eluting stent; new-generation DES; sirolimus-eluting stent; coronary stent; BARE-METAL STENTS; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; NETWORK METAANALYSIS; RANDOMIZED-TRIALS; POOLED ANALYSIS; DRUG; THROMBOSIS; SAFETY; INTERVENTION;

D O I：

10.3390/ijms17091490

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Ultimaster coronary stent system (Terumo Corporation, Tokyo, Japan) represents a new iteration in drug-eluting stent (DES) technology that has recently received the Conformite Europeenne (CE) mark approval for clinical use. The Ultimaster is a thin-strut, cobalt chromium, biodegradable-polymer, sirolimus-eluting coronary stent. The high elasticity of the biodegradable-polymer (PDLLA-PCL) and the abluminal gradient coating technology are additional novel features of this coronary device. The Ultimaster DES has undergone extensive clinical evaluation in two studies: The CENTURY I and II trials. Results from these two landmark studies suggested an excellent efficacy and safety profile of the Ultimaster DES across several lesion and patient subsets, with similar clinical outcomes to contemporary, new-generation DES. The aim of this review is to summarize the rationale behind this novel DES technology and to provide an update of available evidence about the clinical performance of the Ultimaster DES.

引用

页数：10

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