Alternative translation start sites and hidden coding potential of eukaryotic mRNAs

被引：150

作者：

Kochetov, Alex V. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

来源：

BIOESSAYS | 2008年 / 30卷 / 07期

关键词：

D O I：

10.1002/bies.20771

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative translation is growing rapidly. Also, the frequent occurrence of alternative translation events and their functional significance are supported by the results of computational evaluations. The functional role of alternative translation and its contribution to eukaryotic proteome complexity are discussed.

引用

页码：683 / 691

页数：9

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