SALIVARY TRANSCRIPTOME BIOMARKERS IN ORAL SQUAMOUS CELL CANCER DETECTION

被引：27

作者：

Brinkmann, Ole ^{[1
,2
]}

Wong, David T. W. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dent Res Inst, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg Otolaryngol, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Los Angeles, CA 90024 USA

来源：

ADVANCES IN CLINICAL CHEMISTRY, VOL 55 | 2011年 / 55卷

关键词：

RNA EXPRESSION ANALYSES; NECK-CANCER; RB PATHWAY; CARCINOMA; DISEASE; CARCINOGENESIS; IDENTIFICATION; THIOCYANATE; DIAGNOSTICS; PROTEOMICS;

D O I：

10.1016/B978-0-12-387042-1.00002-2

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

In all, 350,000 new cases of oral cancer are reported annually world wide, 35,000 of these occur in the United States. For decades, the 5-year survival rate has remained low at only 60%, which is mainly due to cancer diagnosis at late and progressed stage. Using saliva as a diagnostic medium could be the key for early detection and thus improved survival rates. Among all salivary constituents, the transcriptome has turned out to be a highly promising biomarker source. So far, seven mRNA and two micro-RNA markers were found to be discriminatory in saliva of oral cancer patients. This review will give an overview on the field of salivary transcriptome research with focus on oral cancer detection as well as the translation of salivary diagnostics into clinical reality.

引用

页码：21 / 34

页数：14

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