Controlling molecular transport through nanopores

被引：148

作者：

Keyser, Ulrich F. ^{[1
]}

机构：

[1] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2011年 / 8卷 / 63期

基金：

英国工程与自然科学研究理事会;

关键词：

nanopore; optical tweezers; translocation; single molecules; sensors; SOLID-STATE NANOPORES; DNA HAIRPIN MOLECULES; SINGLE-NUCLEOTIDE RESOLUTION; DIRECT FORCE MEASUREMENTS; PROTEIN NANOPORE; MEMBRANE CHANNEL; ALPHA-HEMOLYSIN; ORIENTATION DISCRIMINATION; POLYNUCLEOTIDE MOLECULES; ELECTRONIC CONTROL;

D O I：

10.1098/rsif.2011.0222

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nanopores are emerging as powerful tools for the detection and identification of macromolecules in aqueous solution. In this review, we discuss the recent development of active and passive controls over molecular transport through nanopores with emphasis on biosensing applications. We give an overview of the solutions developed to enhance the sensitivity and specificity of the resistive-pulse technique based on biological and solid-state nanopores.

引用

页码：1369 / 1378

页数：10

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