Prohepcidin levels during human perinatal adaptation

被引：12

作者：

Balogh, A. ^{[1
]}

Szabo, M. ^{[1
]}

Kelen, D. ^{[1
]}

Bokodi, G. ^{[1
]}

Prechl, J. ^{[2
]}

Bosze, Sz. ^{[3
]}

Vasarhelyi, B. ^{[4
]}

机构：

[1] Semmelweis Univ, Dept Pediat 1, H-1083 Budapest, Hungary

[2] Hungarian Acad Sci, Immunol Res Grp, Budapest, Hungary

[3] Hungarian Acad Sci, Res Grp Peptide Chem, Budapest, Hungary

[4] Hungarian Acad Sci, Res Lab Pediat & Nephrol, Budapest, Hungary

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2007年 / 24卷 / 5-8期

基金：

匈牙利科学研究基金会;

关键词：

iron homeostasis; newborns; perinatal adaptation; prohepcidin;

D O I：

10.1080/08880010701391705

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to test for the presence of prohepcidin in cord blood, to gauge its alteration during the early postnatal period, and to look for a possible association with neonatal iron homeostasis. Cord blood and postnatal venous blood samples were taken from 20 healthy neonates. In both kinds of samples the presence prohepcidin could be detected. No association was found between cord blood and postnatal samples prohepcidin and iron homeostasis. However, an association is demonstrated between cord blood prohepcidin values and mean cell hemoglobin. concentration (MCHC). Prohepcidin increased postnatally it?, half of the neonates, indicating the active synthesis of the molecule. Interestingly, neonates with detectable non-protein bound iron levels in cord blood were presented with lower prohepcidin concentrations. Association between cord blood peohepcidin and MCHC may suggest a possible link between hepcidin and fetal iron homeostasis.

引用

页码：361 / 368

页数：8

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