IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions

被引:184
作者
Matsuki, T [1 ]
Horai, R [1 ]
Sudo, K [1 ]
Iwakura, Y [1 ]
机构
[1] Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, Toyota 1088639, Japan
关键词
IL-1-deficient mouse; IL-1 receptor antagonist-deficient mouse; obese; skinny model; energy homeostasis;
D O I
10.1084/jem.20030299
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IL-1 is a proinflammatory cytokine that plays important roles in inflammation. However, the role of this cytokine under physiological conditions is not known completely. In this paper, we analyzed the role of IL-1 in maintaining body weight because IL-1 receptor antagonist-deficient (IL-1Ra(-/-)) mice, in which excess IL-1 signaling may be induced, show a lean phenotype. Body fat accumulation was impaired in IL-1Ra(-/-) mice, but feeding behavior, expression of hypothalamic factors involved in feeding control, energy expenditure, and heat production were normal. When IL-1Ra(-/-) mice were treated with monosodium glutamate (MSG), which causes obesity in wild-type mice by ablating cells in the hypothalamic arcuate nucleus, they were resistant to obesity, indicating that excess IL-1 signaling antagonizes the effect of MSG-sensitive neuron deficiency. IL-1Ra(-/-) mice showed decreased weight gain when they were fed the same amount of food as wild-type mice, and lipid accumulation remained impaired even when they were fed a high-fat diet. Interestingly, serum insulin levels and lipase activity were low in IL-1Ra(-/-) mice, and the insulin levels were low in contrast to wild-type mice after MSG treatment. These observations suggest that IL-1 plays an important role in lipid metabolism by regulating insulin levels and lipase activity under physiological conditions.
引用
收藏
页码:877 / 888
页数:12
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