The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders

被引：10
作者：
French, S. W. [1 ]
Mendoza, A. S. [1 ]
Peng, Y. [1 ]
机构：
[1] Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2016年 / 100卷 / 03期
关键词：
Neurofibrillary tangles (NFT); beta amyloid (A beta); Protein quality control; 26S proteasome; UBIQUITIN-PROTEASOME PATHWAY; PROTEIN-QUALITY CONTROL; NEUROFIBRILLARY TANGLES; CYTOKERATIN AGGRESOMES; OXIDATIVE STRESS; LIVER; BODIES; MUTANT; INHIBITION; P62;
D O I：
10.1016/j.yexmp.2016.03.010
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins could prevent AD. We compared the literature on MDBs and AD pathogenesis, which include roles played by p62, ubiquitin UBB +1, HSPs70, 90, 104, FAT10, NEDD8, VCP/97, and the protein quality control mechanisms including the 26s proteasome, the IPOD and JUNQ and autophagosome pathways. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：426 / 433
页数：8
相关论文
共 65 条
[1]   M-30 and 4HNE are sequestered in different aggresomes in the same hepatocytes [J].
Amidi, Fataneh ;
French, Barbara A. ;
Chung, David ;
Halsted, Charles H. ;
Medici, Valentina ;
French, Samuel W. .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2007, 83 (03) :296-300
[2]   Modifications in P62 occur due to proteasome inhibition in alcoholic liver disease [J].
Bardag-Gorce, F ;
Francis, T ;
Nan, L ;
Li, J ;
Lue, YH ;
French, BA ;
French, SW .
LIFE SCIENCES, 2005, 77 (20) :2594-2602
[3]   Proteasome inhibition induces cytokeratin accumulation in vivo [J].
Bardag-Gorce, F ;
Vu, J ;
Nan, L ;
Riley, N ;
Li, J ;
French, SW .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2004, 76 (02) :83-89
[4]   The mechanism of cytokeratin aggresome formation:: the role of mutant ubiquitin (UBB+1) [J].
Bardag-Gorce, F ;
Riley, N ;
Nguyen, V ;
Montgomery, RO ;
French, BA ;
Li, J ;
van Leeuwen, FW ;
Lungo, W ;
McPhaul, LW ;
French, SW .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2003, 74 (02) :160-167
[5]   The role of the ubiquitin-proteasome pathway in the formation of Mallory bodies [J].
Bardag-Gorce, F ;
van Leeuwen, FW ;
Nguyen, V ;
French, BA ;
Li, J ;
Riley, N ;
McPhaul, LW ;
Lue, YH ;
French, SW .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2002, 73 (02) :75-83
[6]   CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation [J].
Bardag-Gorce, Fawzia ;
French, Barbara A. ;
Nan, Li ;
Song, Helen ;
Nguyen, Sheila Khanh ;
Yong, Holly ;
Dede, Jennifer ;
French, Samuel W. .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2006, 81 (03) :191-201
[7]   SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model [J].
Bardag-Gorce, Fawzia ;
Oliva, Joan ;
Li, Jun ;
French, Barbara A. ;
French, Samuel W. .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2010, 88 (03) :353-362
[8]   The UPS and autophagy in chronic neurodegenerative disease Six of one and half a dozen of the other-or not? [J].
Bedford, Lynn ;
Paine, Simon ;
Rezvoni, Nooshin ;
Mee, Maureen ;
Lowe, James ;
Mayer, R. John .
AUTOPHAGY, 2009, 5 (02) :224-227
[9]   Impairment of the ubiquitin-proteasome system by protein aggregation [J].
Bence, NF ;
Sampat, RM ;
Kopito, RR .
SCIENCE, 2001, 292 (5521) :1552-1555
[10]   Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death [J].
De Vrij, FMS ;
Sluijs, JA ;
Gregori, L ;
Fischer, DF ;
Hermens, WTJMC ;
Goldgaber, D ;
Verhaagen, J ;
Van Leeuwen, FW ;
Hol, EM .
FASEB JOURNAL, 2001, 15 (14) :2680-2688
1234567