Microwave-Promoted Catalyst- and Solvent-Free Aza-Diels-Alder Reaction of Aldimines with 6-[2-(Dimethylamino)vinyl]-1,3-dimethyluracil

被引：29

作者：

Sarma, Rupam ^{[1
]}

Sarmah, Manas M. ^{[1
]}

Prajapati, Dipak ^{[1
]}

机构：

[1] CSIR NE Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 04期

关键词：

TYROSINE KINASE INHIBITORS; ORGANIC-SYNTHESIS; KETONES; DERIVATIVES; CYCLIZATION; PYRIMIDINE;

D O I：

10.1021/jo202346w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microwave-promoted aza-Diels Alder reaction between 6[2-(dimethylamino)vinyl]-1,3-dimethyluracil and aldimines has been developed for the construction of dihydropyrido[4,3-d]pyrimidines. Urea is effectively employed as an environmentally benign source of ammonia in the absence of any catalyst or solvent. The key step in the reaction is in situ generation and trapping of the reactive aldimine formed from urea and aldehyde by the diene system of the uracil. The reaction is clean, and excellent yields are obtained in a matter of a few minutes.

引用

页码：2018 / 2023

页数：6

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