Faulty serotonin - DHEA interactions in autism: results of the 5-hydroxytryptophan challenge test

被引:1
作者
Croonenberghs, Jan [1 ]
Spaas, Kristien [1 ]
Wauters, Annick [2 ]
Verkerk, Robert [3 ]
Scharpe, Simon [3 ]
Deboutte, Dirk [1 ]
Maes, Michael [4 ]
机构
[1] Univ Antwerp, Fac Med, AZ Middelheim, Univ Ctr Child & Adolescent Psychiat, B-2020 Antwerp, Belgium
[2] AZ Middelheim, Lab Clin Biol, Antwerp, Belgium
[3] Univ Antwerp, Dept Med Biochem, Edegem, Belgium
[4] Clin Res Ctr Mental Hlth, Antwerp, Belgium
关键词
autism; serotonin; cortisol; DHEA; L-5-hydroxytryptophan; neurogenesis; neurodegeneration; neurotoxic; stress;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: Autism is accompanied by peripheral and central disorders in the metabolism of serotonin (5-HT). The present study examines plasma dehydroepiandrosterone-sulphate (DHEA-S) and the cortisol/DHEA-S ratio following administration of L-5-hydroxytryptophan (5-HTP), the direct precursor of 5-HT, to autistic patients. METHODS: Plasma DHEA-S levels were determined both before and after administration of 5-HTP or placebo, on two consecutive days in a single blind order in 18 male autistic patients and 22 matched healthy controls. RESULTS: The 5-HTP-induced DHEA-S responses were significantly higher in autistic patients than in controls. In baseline conditions, the cortisol/DHEA-S ratio was significantly higher in autistic patients than in controls. Discussion: The results suggest that autism is accompanied by a major disequilibrium in the serotonergic system. The increased Cortisol (neurotoxic) versus DHEA-S (neuroprotective) ratio suggests that an increased neurotoxic potential occurs in autism. CONCLUSIONS: It is concluded that a disequilibrium in the peripheral and central turnover of serotonin and an increased neurotoxic capacity by glucocorticoids are important pathways in autism.
引用
收藏
页码:385 / 390
页数:6
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