Oncogenic PI3K deregulates transcription and translation

被引：663
作者：
Bader, AG [1 ]
Kang, SY [1 ]
Zhao, L [1 ]
Vogt, PK [1 ]
机构：
[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 12期
关键词：
D O I：
10.1038/nrc1753
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer pathogenesis. Experimental data document a requirement for deregulation of both transcription and translation in PI3K-mediated oncogenic transformation. The recent discoveries of cancer-specific mutations in PIK3CA, the gene that encodes the catalytic subunit p110 alpha of PI3K, have heightened the interest in the oncogenic potential of this lipid kinase and have made p110 alpha an ideal drug target.
引用
收藏
页码：921 / 929
页数：9
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