Voltammetric determination of paracetamol using a glassy carbon electrode modified with Prussian Blue and a molecularly imprinted polymer, and ratiometric read-out of two signals

被引:37
作者
Dai, Yunlong [1 ,2 ,3 ]
Li, Xueyan [1 ,2 ,3 ]
Lu, Xiaojing [1 ,2 ,3 ]
Kan, Xianwen [1 ,2 ,3 ]
机构
[1] Anhui Normal Univ, Coll Chem & Mat Sci, Wuhu 241000, Peoples R China
[2] Anhui Normal Univ, Key Lab Funct Mol Solids, Minist Educ, Wuhu 241000, Peoples R China
[3] Anhui Normal Univ, Anhui Key Lab Chemobiosensing, Anhui Lab Mol Based Mat, Wuhu 241000, Peoples R China
基金
中国国家自然科学基金;
关键词
Electroanalysis; Electropolymerization; Paracetamol detection; Cyclic voltammetry; Differential pulse voltammetry; Ratiometric sensor; Recognition; ELECTROCHEMICAL SENSOR; CONDUCTING POLYMER; MEDIATED AMPLIFICATION; ACID; NANOTUBES; GRAPHENE; DOPAMINE; RECOGNITION; POLYPYRROLE; FILM;
D O I
10.1007/s00604-016-1926-0
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The authors report on a ratiometric electrochemical sensor for paracetamol (PR) which was fabricated by successively electropolymerizing a layer of Prussian blue (PB) and a layer of molecularly imprinted polypyrrole (MIP) on the surface of a glassy carbon electrode (GCE). The binding of PR molecules to the MIP has two effects: The first is an increase of the oxidation current for PR at 0.42 V (vs. SCE), and the second is a decrease in the current for PB (at 0.18 V) due to partial blocking of the channels which results in reduced electron transmissivity. Both currents, and in particular their ratio, can serve as analytical information. Under optimized conditions, the sensor displays enhanced sensitivity for PR in the 1.0 nM to 0.1 mM concentration range and a 0.53 nM lower limit of detection. The sensor was applied to the determination of PR in tablets and urines where it gave recoveries in the range between 94.6 and 104.9 %. This dual-signal (ratiometric) detection scheme (using electropolymerized Prussian Blue and analyte-specific MIP) in our perception has a wide scope in that it may be applied to numerous other electroactive species for which specific MIP can be made available.
引用
收藏
页码:2771 / 2778
页数:8
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