In vitro antisickling activity of cromolyn sodium

被引：9

作者：

Fall, ABK

Toppet, M

Ferster, A

Fondu, P

Vanhaelen-Fastré, R

Vanhaelen, M

机构：

[1] Free Univ Brussels, Inst Pharm, Lab Pharmacognosie & Bromatol, B-1050 Brussels, Belgium

[2] Hop Univ Enfants Reine Fabiola, Unit Hematooncol, Brussels, Belgium

[3] Free Univ Brussels, Hop Univ Brugmann, Hematol Lab, B-1020 Brussels, Belgium

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 103卷 / 04期

关键词：

cromolyn sodium; antisickling activity; corpuscular indices;

D O I：

10.1046/j.1365-2141.1998.01106.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The improvement in sickle cell disease (SCD) children receiving cromolyn sodium therapy prompted us to investigate its antisickling activity in vitro. The number of sickle cells was determined in deoxygenated blood samples from 15 children with severe SCD. At the eight concentrations tested, cromolyn sodium exhibited a significantly higher activity than pentoxifylline, the standard compound. Therefore cromolyn sodium would appear to be an interesting candidate for SCD therapy and deserves further in vivo investigations.

引用

页码：957 / 959

页数：3

共 7 条

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