Macrophage migration inhibitory factor in cancer

被引：30

作者：

Yasasever, Vildan ^{[1
]}

Camlica, Hakan ^{[2
]}

Duranyildiz, Derya ^{[1
]}

Oguz, Hilal ^{[1
]}

Tas, Faruk ^{[3
]}

Dalay, Nejat ^{[1
]}

机构：

[1] Istanbul Univ, Inst Oncol, Dept Basic Oncol, TR-34390 Istanbul, Turkey

[2] Istanbul Univ, Inst Oncol, Dept Prevent Oncol Biostat & Epidemiol, Istanbul, Turkey

[3] Istanbul Univ, Inst Oncol, Dept Med Oncol, Istanbul, Turkey

来源：

CANCER INVESTIGATION | 2007年 / 25卷 / 08期

关键词：

MIF; colorectal cancer; malignant melanoma; tumor marker; ELISA;

D O I：

10.1080/07357900701560695

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this study was to investigate the expression of macrophage migration inhibitory factor (MIF) in patients with colorectal cancer (GIS) and malignant melanoma (MM). The study group consists of pathologically verified colorectal cancer (n = 63) and malignant melanoma (n = 65) pateints and healthy controls (n = 25). Serum MIF concentrations were determined by enyzme-linked immunosorbent assay. Serum values of the patients were significantly higher than the controls (p < 0.001 for GIS, p = 0.032 for MM). Diagnostic sensitivity and specificity were calculated for MIF for colorectal and malignant melanoma. The results demonstrate that colorectal cancer express and secrete large amounts of MIF.

引用

页码：715 / 719

页数：5

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