Hydrotropes are compounds able to enhance the solubility of hydrophobic substances in aqueous media and therefore are widely used in the formulation of drugs, cleaning and personal care products. In this work, it is shown that ionic liquids are a new class of powerful catanionic hydrotropes where both the cation and the anion synergistically contribute to increase the solubility of biomolecules in water. The effects of the ionic liquid chemical structures, their concentration and the temperature on the solubility of two model biomolecules, vanillin and gallic acid were evaluated and compared with the performance of conventional hydrotropes. The solubility of these two biomolecules was studied in the entire composition range, from pure water to pure ionic liquids, and an increase in the solubility of up to 40-fold was observed, confirming the potential of ionic liquids to act as hydrotropes. Using dynamic light scattering, NMR and molecular dynamics simulations, it was possible to infer that the enhanced solubility of the biomolecule in the IL aqueous solutions is related to the formation of ionic-liquid-biomolecules aggregates. Finally, it was demonstrated that hydrotropy induced by ionic liquids can be used to recover solutes from aqueous media by precipitation, simply by using water as an anti-solvent. The results reported here have a significant impact on the understanding of the role of ionic liquid aqueous solutions in the extraction of value-added compounds from biomass as well as in the design of novel processes for their recovery from aqueous media.
机构:
Lab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, PortugalLab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Bogel-Lukasik, Rafal
Nobre Goncalves, Linda Maria
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Lab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, PortugalLab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Nobre Goncalves, Linda Maria
Bogel-Lukasik, Ewa
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Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, PortugalLab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
机构:
Univ York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England
Booth, Jonathan J.
Abbott, Steven
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Steven Abbott TCNF Ltd, Ipswich IP1 3SZ, Suffolk, EnglandUniv York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England
机构:
Lab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, PortugalLab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Bogel-Lukasik, Rafal
Nobre Goncalves, Linda Maria
论文数: 0引用数: 0
h-index: 0
机构:
Lab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, PortugalLab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
Nobre Goncalves, Linda Maria
Bogel-Lukasik, Ewa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, PortugalLab Nacl Energia & Geol, IP Unit Bioenergy, P-1649038 Lisbon, Portugal
机构:
Univ York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England
Booth, Jonathan J.
Abbott, Steven
论文数: 0引用数: 0
h-index: 0
机构:
Steven Abbott TCNF Ltd, Ipswich IP1 3SZ, Suffolk, EnglandUniv York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England