microRNAs: Potential Targets for the Treatment of Cardiovascular Disease

被引：8

作者：

Athyros, Vasilios G. ^{[1
]}

Katsiki, Niki ^{[1
]}

Karagiannis, Asterios ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Med, Hippokrat Hosp, Propedeut Dept Internal Med 2, Thessaloniki 55132, Greece

来源：

CURRENT VASCULAR PHARMACOLOGY | 2015年 / 13卷 / 03期

关键词：

microRNA; cardiovascular disease; obesity; metabolic syndrome; diabetes; antisense oligonucleotides; silencing; microRNA mimics; EXPRESSION; MIR-126;

D O I：

10.2174/157016111303150707103801

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several non-coding microRNAs (miRs) are implicated in the pathogenesis of obesity, metabolic syndrome, diabetes mellitus, atherosclerosis and cardiovascular disease. Some of these miRs are beneficial but others are hazardous. Silencing of the latter by antisense oligonucleotides has been attempted in animal models with promising results. However, the replacement of down-regulated beneficial miRs, by manufactured miR mimics, or increasing their expression is much more demanding and has several limitations. The treatment of cardiovascular diseases through miR manipulation shows potential, provided safety and cost effectiveness issues are considered carefully before implementation in humans.

引用

页码：366 / 367

页数：2

共 23 条

[1] miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity [J].

Allen, Ryan M. ;

Marquart, Tyler J. ;

Albert, Carolyn J. ;

Suchy, Frederick J. ;

Wang, David Q. -H. ;

Ananthanarayanan, Meenakshisundaram ;

Ford, David A. ;

Baldan, Angel .

EMBO MOLECULAR MEDICINE, 2012, 4 (09) :882-895

[2] Emerging Role of MicroRNAs in Cardiovascular Diseases [J].

De Rosa, Salvatore ;

Curcio, Antonio ;

Indolfi, Ciro .

CIRCULATION JOURNAL, 2014, 78 (03) :567-575

[3] MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3 [J].

Fasanaro, Pasquale ;

D'Alessandra, Yuri ;

Di Stefano, Valeria ;

Melchionna, Roberta ;

Romani, Sveva ;

Pompilio, Giulio ;

Capogrossi, Maurizio C. ;

Martelli, Fabio .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (23) :15878-15883

[4]

Fernandez-Hernando Carlos, 2013, Curr Genet Med Rep, V1, P30

[5] MiR-126 regulates angiogenic signaling and vascular integrity [J].

Fish, Jason E. ;

Santoro, Massimo M. ;

Morton, Sarah U. ;

Yu, Sangho ;

Yeh, Ru-Fang ;

Wythe, Joshua D. ;

Lvey, Kathryn N. ;

Bruneau, Benoit G. ;

Stainier, Didier Y. R. ;

Srivastava, Deepak .

DEVELOPMENTAL CELL, 2008, 15 (02) :272-284

[6] Diabetes mellitus, a microRNA-related disease? [J].

Guay, Claudiane ;

Roggli, Elodie ;

Nesca, Valeria ;

Jacovetti, Cecile ;

Regazzi, Romano .

TRANSLATIONAL RESEARCH, 2011, 157 (04) :253-264

[7] MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1 [J].

Harris, Tamia A. ;

Yamakuchi, Munekazu ;

Ferlito, Marcella ;

Mendell, Joshua T. ;

Lowenstein, Charles J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) :1516-1521

[8] Role of microRNAs in obesity and the metabolic syndrome [J].

Heneghan, H. M. ;

Miller, N. ;

Kerin, M. J. .

OBESITY REVIEWS, 2010, 11 (05) :354-361

[9] Bone Morphogenetic Protein 4 Promotes Vascular Smooth Muscle Contractility by Activating MicroRNA-21 (miR-21), which Down-regulates Expression of Family of Dedicator of Cytokinesis (DOCK) Proteins [J].

Kang, Hara ;

Davis-Dusenbery, Brandi N. ;

Nguyen, Peter H. ;

Lal, Ashish ;

Lieberman, Judy ;

Van Aelst, Linda ;

Lagna, Giorgio ;

Hata, Akiko .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (06) :3976-3986

[10] MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion [J].

Maegdefessel, Lars ;

Azuma, Junya ;

Toh, Ryuji ;

Deng, Alicia ;

Merk, Denis R. ;

Raiesdana, Azad ;

Leeper, Nicholas J. ;

Raaz, Uwe ;

Schoelmerich, Anke M. ;

McConnell, Michael V. ;

Dalman, Ronald L. ;

Spin, Joshua M. ;

Tsao, Philip S. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (122)

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