Decline in bone mineral density with stress fractures in a woman on depot medroxyprogesterone acetate - A case report

被引:0
作者
Harkins, GJ [1 ]
Davis, GD
Dettori, J
Hibbert, ML
Hoyt, RA
机构
[1] Madigan Army Med Ctr, Dept Obstet & Gynecol, Tacoma, WA 98431 USA
[2] Madigan Army Med Ctr, Dept Urogynecol, Tacoma, WA 98431 USA
[3] Madigan Army Med Ctr, Dept Phys Therapy, Tacoma, WA 98431 USA
[4] Madigan Army Med Ctr, Dept Reprod Endocrinol, Tacoma, WA 98431 USA
关键词
depot medroxyprogesterone acetate; bone mineral density; fractures; stress;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: Depot medroxyprogesterone acetate is a popular contraceptive among young, physically active women. However, its administration has been linked to a relative decrease in estrogen levels. Since bone resorption is accelerated during hypoestrogenic states, there has been growing concern about the potential development of osteoporosis and fractures with the use of this contraceptive method. CASE: A physically active, 33-year-old woman demonstrated a 12.4% drop in femoral neck bone mineral density (BMD), 6.4% drop in lumbar BMD and 0.8% drop in total BMD with the subsequent development of a tibial stress fracture while on depot medroxyprogesterone acetate. Bone mineralization vapidly improved, and the stress fracture resolved with discontinuation of the medication. CONCLUSION: The long-term effects of depot medroxyprogesterone acetate on bone mineralization in physically active women should be evaluated more thoroughly.
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页码:309 / 312
页数:4
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