Synthesis and immunotropic activity of methyl esters of 2-alkylaminomethylene-3-oxolup-20(29)-en-28-ic acids

被引:2
作者
Tolmacheva, I. A. [1 ]
Anikina, L. V. [1 ]
Vikharev, Yu. B. [1 ]
Igosheva, E. V. [2 ]
Shelepen'kina, L. N. [1 ]
Grishko, V. V. [1 ]
Tolstikov, A. G. [1 ]
机构
[1] Russian Acad Sci, Inst Tech Chem, Ural Div, Perm 614013, Russia
[2] Perm State Univ, Perm 614600, Russia
关键词
triterpenoids; lupane; betulonic acid; beta-enaminoketones; immunotropic activity;
D O I
10.1134/S1068162008040146
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
New lupane beta-enaminoketones were synthesized by interaction of methyl 2-hydroxymethylene-3-oxolup-20(29)-en-28-oate with aliphatic amines. Immunotropic activity was found for some of these compounds.
引用
收藏
页码:483 / 487
页数:5
相关论文
共 13 条
[1]  
Fieser LF, 1968, REAGENTS ORGANIC SYN
[2]  
Flekhter O. B., 2002, Khimiko-Farmatsevticheskii Zhurnal, V36, P26
[3]  
KEIL B, 1966, LAB TEKHNIKA ORGANIC
[4]   TRITERPENES .59. PREPARATION OF 2-METHYL-3-OXO TRITERPENOIDS OF 18-ALPHA-OLEANANE SERIES AND THE CONFORMATION OF RING-A [J].
KLINOT, J ;
SVETLY, J ;
KUDLACKOVA, D ;
BUDESINSKY, M ;
VYSTRCIL, A .
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1979, 44 (01) :211-225
[5]  
*PHARM COMM, 2000, RUK EKSP KOKL IZ NOV
[6]  
SIEGL E, 1976, IMMUNOLOGISCHE ARBEI
[7]   Synthesis and immunotropic activity of 2-alkylaminomethylene-19β,28-epoxyolean-3-ones [J].
Tolmacheva, I. A. ;
Anikina, L. V. ;
Vikharev, Yu. B. ;
Shelepen'kina, L. N. ;
Grishko, V. V. ;
Tolstikov, A. G. .
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2008, 34 (01) :125-129
[8]  
Tolstikova T G, 2006, Bioorg Khim, V32, P42
[9]   Biological activity and pharmacological prospects of lupane terpenoids: II. Semisynthetic lupane derivatives [J].
Tolstikova, T. G. ;
Sorokina, I. V. ;
Tolstikov, G. A. ;
Tolstikov, A. G. ;
Flekhter, O. B. .
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2006, 32 (03) :261-276
[10]   Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives [J].
Tolstikova, TG ;
Sorokina, IV ;
Tolstikov, GA ;
Tolstikov, AG ;
Flekhter, OB .
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2006, 32 (01) :37-49