Palladium-catalyzed intermolecular aerobic oxidative amination of terminal alkenes: Efficient synthesis of linear allylamine derivatives

被引：225
作者：
Liu, Guosheng [1 ]
Yin, Guoyin [1 ]
Wu, Liang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 25期
关键词：
alkenes; allylic compounds; amination; oxidation; palladium;
D O I：
10.1002/anie.200801009
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) O2-coupledallylic C-H amination: A first general palladium-mediated intermolecular aerobic oxidative allylic amination was developed to synthesize linear (E)-allylimides with high regioselectivity (see scheme; MA = maleic anhydride). The proposed mechanism involves an allylic C-H activation with subsequent nitrogen nucleophile substitution. The catalytic system allows efficient dioxygen-coupled turnover without additional cocatalysts. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：4733 / 4736
页数：4
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