Synthesis and antioxidant activity of 3,3′-diselanediylbis (N,N-disubstituted indolizine-1-carboxamide) and derivatives

被引：0

作者：

Narajji, Chandrashekhar ^{[1
]}

Karvekar, Manohar D. ^{[1
]}

Das, A. Kumar ^{[1
]}

机构：

[1] Krupanidhi Coll Pharm, Dept Pharmaceut Chem, Bangalore 560034, Karnataka, India

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2008年 / 61卷

关键词：

antioxidants; diselenides; indolizine; free radical scavenger; 1,1-DPPH center dot;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel diselenides 5a-e were synthesized from alpha-haloketones, alpha-picoline alkenes and various secondary amines under a dry nitrogen atmosphere. The structures of these compounds were established by means of their spectral data and they were screened for scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH.). The results of this research showed that two of these compounds (5e and 5d) exhibited reasonable antioxidant activity. The intermediate, methyl 5-methylindolizine-1-carboxylate was prepared by condensation of methyl acrylate with 1-(carboxymethyl)-2-methylpyridinium halide, which was prepared from alpha-picoline and chloroacetic acid by using the Tschischibabin reaction.

引用

页码：53 / 55

页数：3

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