Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update

被引:7
作者
Rasmi, Yousef [1 ,2 ]
Mosa, Osama F. [3 ,4 ]
Alipour, Shahriar [2 ]
Heidari, Nadia [5 ]
Javanmard, Farzaneh [6 ]
Golchin, Ali [2 ]
Gholizadeh-Ghaleh Aziz, Shiva [2 ,7 ]
机构
[1] Urmia Univ Med Sci, Cellular & Mol Res Ctr, Orumiyeh, Iran
[2] Urmia Univ Med Sci, Sch Med, Dept Biochem, Orumiyeh, Iran
[3] Umm Al Qura Univ, Dept Publ Hlth, Hlth Sci Coll Lieth, Mecca, Saudi Arabia
[4] Bukhara State Med Inst, Dept Biochem, Bukhara, Uzbekistan
[5] Golestan Univ Med Sci, Dept Clin Biochem, Metab Disorders Res Ctr, Gorgan, Golestan, Iran
[6] Urmia Univ Med Sci, Dept Pathol, Orumiyeh, Iran
[7] Urmia Univ Med Sci, Nephrol & Kidney Transplant Res Ctr, Clin Res Inst, Orumiyeh, Iran
关键词
cardiovascular disease; troponin; COVID-19; biosensor; SARS-CoV-2; diagnostic value; SURFACE-PLASMON RESONANCE; DISEASE; 2019; COVID-19; GRAPHENE OXIDE; ELECTROCHEMICAL IMMUNOSENSOR; MYOCARDIAL-INFARCTION; GOLD NANOPARTICLES; SLOW-TWITCH; CHEST CT; CORONAVIRUS; TROPOMYOSIN;
D O I
10.3389/fmolb.2022.821155
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Coronavirus disease 2019 (COVID-19) has rapidly developed as a global health emergency. Respiratory diseases are significant causes of morbidity and mortality in these patients with a spectrum of different diseases, from asymptomatic subclinical infection to the progression of severe pneumonia and subsequent acute respiratory distress syndrome. Individuals with cardiovascular disease are more likely to become infected with SARS-CoV-2 and develop severe symptoms. Hence, patients with underlying cardiovascular disease mortality rate are over three times. Furthermore, note that patients with a history of cardiovascular disease are more likely to have higher cardiac biomarkers, especially cardiac troponins, than infected patients, especially those with severe disease, making these patients more susceptible to cardiac damage caused by SARS-2-CoV. Biomarkers are important in decision-making to facilitate the efficient allocation of resources. Viral replication in the heart muscle can lead to a cascade of inflammatory processes that lead to fibrosis and, ultimately, cardiac necrosis. Elevated troponin may indicate damage to the heart muscle and may predict death. After the first Chinese analysis, increased cardiac troponin value was observed in a significant proportion of patients, suggesting that myocardial damage is a possible pathogenic mechanism leading to severe disease and death. However, the prognostic performance of troponin and whether its value is affected by different comorbidities present in COVID-19 patients are not known. This review aimed to assess the diagnostic value of troponin to offer insight into pathophysiological mechanisms and reported new assessment methods, including new biosensors for troponin in patients with COVID-19.
引用
收藏
页数:17
相关论文
共 180 条
[1]   Development of optical biosensor technologies for cardiac troponin recognition [J].
Abdolrahim, Mojgan ;
Rabiee, Mohammad ;
Alhosseini, Sanaz Naghavi ;
Tahriri, Mohammadreza ;
Yazdanpanah, Sara ;
Tayebi, Lobat .
ANALYTICAL BIOCHEMISTRY, 2015, 485 :1-10
[2]   COVID-19 and the Heart [J].
Akhmerov, Akbarshakh ;
Marban, Eduardo .
CIRCULATION RESEARCH, 2020, 126 (10) :1443-1455
[3]  
Al-Hadi Hafidh A, 2009, Sultan Qaboos Univ Med J, V9, P231
[4]   Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients [J].
Al-Zakhari, Rana ;
Atere, Muhammed K. O. ;
Lim, William ;
Abdulrahman, Mustafa ;
Akhtar, Shahnaz ;
Sheets, Nicholas ;
Joyce, Thomas ;
Stefanishina, Veronika ;
Appiah-Kubi, Edmund ;
Owusu-Antwi, Philipa ;
Nfonoyim, Jay ;
Grodman, Richard ;
Rotatori, Francesco .
CARDIOLOGY RESEARCH, 2021, 12 (04) :258-264
[5]   Cardiac Troponin - diagnostic problems and impact on cardiovascular disease [J].
Alaour, Bashir ;
Liew, Felicity ;
Kaier, Thomas E. .
ANNALS OF MEDICINE, 2018, 50 (08) :655-665
[6]   Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus [J].
Alhogbani, Tariq .
ANNALS OF SAUDI MEDICINE, 2016, 36 (01) :78-80
[7]   Cardiac Troponin I Levels in Hospitalized COVID-19 Patients as a Predictor of Severity and Outcome: A Retrospective Cohort Study [J].
Ali, Jabar ;
Khan, Fahad R. ;
Ullah, Rizwan ;
Hassan, Zair ;
Khattak, Safi ;
Lakhta, Gul ;
Gul, Nooh Zad ;
Ullah, Rahman .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (03)
[8]   Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19 [J].
Ali, Nurshad .
JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (11) :2409-2411
[9]   Myocardial infarction redefined -: A consensus Document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction [J].
Alpert, JS ;
Antman, E ;
Apple, F ;
Armstrong, PW ;
Bassand, JP ;
de Luna, AB ;
Beller, G ;
Breithardt, G ;
Chaitman, BR ;
Clemmensen, P ;
Falk, E ;
Fishbein, MC ;
Galvani, M ;
Garson, A ;
Grines, C ;
Hamm, C ;
Jaffe, A ;
Katus, H ;
Kjekshus, J ;
Klein, W ;
Klootwijk, P ;
Lenfant, C ;
Levy, D ;
Levy, RI ;
Luepker, R ;
Marcus, F ;
Näslund, U ;
Ohman, M ;
Pahlm, O ;
Poole-Wilson, P ;
Popp, R ;
Alto, P ;
Pyörälä, K ;
Ravkilde, J ;
Rehnquist, N ;
Roberts, W ;
Roberts, R ;
Roelandt, J ;
Rydén, L ;
Sans, S ;
Simoons, ML ;
Thygesen, K ;
Tunstall-Pedoe, H ;
Underwood, R ;
Uretsky, BF ;
Van de Werf, F ;
Voipio-Pulkki, LM ;
Wagner, G ;
Wallentin, L ;
Wijns, W .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (03) :959-969
[10]   Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays [J].
Apple, Fred S. ;
Collinson, Paul O. .
CLINICAL CHEMISTRY, 2012, 58 (01) :54-61