Mesenchymal Stem/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy?

被引：101

作者：

Schaefer, Richard ^{[1
]}

Spohn, Gabriele ^{[1
]}

Baer, Patrick C. ^{[2
]}

机构：

[1] German Red Cross Blood Donor Serv Baden Wurttembe, Goethe Univ Hosp, Inst Transfus Med & Immunohematol, Sandhofstr 1, D-60528 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Dept Internal Med 3, Div Nephrol, Frankfurt, Germany

来源：

TRANSFUSION MEDICINE AND HEMOTHERAPY | 2016年 / 43卷 / 04期

关键词：

Bone marrow; Stem cell transplantation; Stem cells; Stroke; EPIDERMAL-GROWTH-FACTOR; MULTIPOTENTIAL STROMAL CELLS; GAP-JUNCTION FORMATION; UMBILICAL-CORD BLOOD; VERSUS-HOST-DISEASE; STEM-CELLS; BONE-MARROW; MYOCARDIAL-INFARCTION; EXTRACELLULAR VESICLES; TISSUE-REPAIR;

D O I：

10.1159/000447458

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the development of cell therapeutics in regenerative medicine. Featuring immunomodulatory potential as well as secreting a variety of trophic factors, MSCs showed remarkable therapeutic effects in numerous preclinical disease models. However, sustainable translation of MSC therapies to the clinic is hampered by heterogeneity of MSCs and non-standardized in vitro culture technologies. Moreover, potent MSC therapeutics require MSCs with maximum regenerative capacity. There is growing evidence that in vitro preconditioning strategies of MSCs can optimize their therapeutic potential. In the following we will discuss achievements and challenges of the development of MSC therapies in regenerative medicine highlighting specific in vitro preconditioning strategies prior to cell transplantation to increase their therapeutic efficacy. (C) 2016 S. Karger GmbH, Freiburg

引用

页码：256 / 267

页数：12

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