Pathogenesis of influenza A (H5N1) virus infection in a primate model

被引：202
|
作者：
Rimmelzwaan, GF
Kuiken, T
van Amerongen, G
Bestebroer, TM
Fouchier, RAM
Osterhaus, ADME
机构：
[1] Erasmus Univ, Inst Virol, Natl Influenza Ctr, Ctr Med, NL-3000 DR Rotterdam, Netherlands
[2] Natl Inst Publ Hlth & Environm, Cent Anim Lab, NL-3720 BA Bilthoven, Netherlands
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 14期
关键词：
D O I：
10.1128/JVI.75.14.6687-6691.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.
引用
收藏
页码：6687 / 6691
页数：5
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